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Crypto using the Disintegrator
The Disintegrator Ray is the third weapon Crypto received in Destroy All Humans!.
Overview
The Disintegrator is introduced in the first mission of Santa Modesta after you crash the mayor's pool party.
It fires molten balls of energy like an assault rifle (although it is often mistaken for lava/fire). It only takes a few bursts to turn a human into a pile of ashes. He also uses it to destroy obstacles and blow up vehicles.
It is wielded by Crypto in the box art of all the games.