Crypto using the Disintegrator
The Disintegrator Ray (also called the "Destructo Ray" in the first game) is the third weapon Crypto received in Destroy All Humans!.
Overview
The Disintegrator is introduced in the first mission of Santa Modesta after you crash the mayor's pool party.
It fires a molten ball of energy like an assault rifle (although it is often mistaken for lava/fire). It only takes a few bursts to turn a human into a pile of ashes.
It is wielded by Crypto in the box art of all the games.
Images
The new Disintegrator