The Anal Probe is one of Crypto's weapons, used throughout all the Destroy All Humans! games.
This weapon, when used, will drill into a human's anus and make his head explode, extracting the brain stem for obtaining Furon DNA. The Anal Probe is portrayed in different ways throughout each game, with each one upgrading its capabilities.
The Anal Probe in the first game is a small, black gun with a green blob on the back. It works by being charged and then shot at a human. A fully charged shot can send a civilian or a policeman running before their heads explode, allowing Crypto to collect the brain stems. Two fully charged shots are needed to take down a soldier, whereas three shots are needed to take down a Majestic agent or a Psi-Mutant. It does not require ammo and is the only weapon that cannot be upgraded by Pox. This is the only anal probe that doesn't require ammo, but for immediate extraction then charging it up is necessary.
In the second game, the Anal Probe looks the same as before but now requires ammo. Setting the trend for the next installments, the Anal Probe can instantly kill a human. Human brains can still be collected, though it is only for energy used for Crypto's Mind Flash. Using the weapon on a Blisk Mutant extracts its spores and turns it back into its human form. Upgrading it increases the ammo.
Big Willy Unleashed
In the third game, the Anal Probe gains a new look, resembling a bowcaster. This Anal Probe doesn't need ammo since any shots fired return when the target's brain stem has been ripped out. Upgrading it allows for more shots to be fired while also gaining the ability to actually bring the stems to Crypto.
Path of the Furon
In the fourth game, the Anal Probe gains another new look, now dubbed the Orthopox AP-77 Anal Probe, and now resembles a grenade launcher. This Anal Probe requires ammo once again, but is able to lock on to multiple human targets. Unlike previous incarnations. which does no damage against bosses, this one can.